Preimplantation Genetic Testing for Monogenic or Single gene defects (PGT-M)
PGT-M tests the embryos for specific diseases. If you or someone in your family has a known inheritable condition, or if your carrier testing shows that you and your partner are both carriers for the same condition (for example, cystic fibrosis), testing of the embryo for the specific disease in question can also be accomplished. Embryos that are negative for the disease following testing, can then be placed back into the uterus.
Preimplantation Genetic Testing for Structural Rearrangements (PGT-SR)
PGT-SR tests embryos for the presence of aneuploidy as a result of a parental chromosome translocation. <1% of the general population, and approximately 4% of couples with recurrent pregnancy loss, harbor a chromosome translocation. The most common type of translocation is a balanced translocation. With this, carriers have a normal amount of genetic material in the majority of their cells, however, the genetic material is arranged in an abnormal way. Additionally, eggs and sperm of translocation carriers have a higher chance of being aneuploid, which leads to a higher chance for an aneuploid embryo, and ultimately a higher chance for miscarriage. Testing of embryos for these structural rearrangements may help to reduce the chance for miscarriage.