Social Accounts Sprite
RMI

PCOS, Clomid and Letrozole...oh my!

By Team RMI on August 06, 2014

Traditionally, Clomid have been used to induce ovulation for women with PCOS. Clomid was discovered decades ago and is considered an “old champion” of ovulation induction. The ovulation rates for Clomid are reasonable, however because Clomid is an anti-estrogen in the cervical mucus and uterine lining, pregnancy rates are about 10-15% per ovulation induction cycle.

Another medication for ovulation induction, Letrazole, has been available for more than 10 years. However, the use of this drug was discouraged when one study suggested the link between using Letrazole for ovulation induction and birth defects. The study was poorly planned and heavily criticized, but the concern remain valid for some time.

Recently a new study was published in the New England Journal of Medicine. The study compared live birth rates of patients with PCOS who used Letrozole or Clomid to induce ovulation and to get pregnant. The study demonstrated that women who received Letrozole also had a higher ovulation rate (61.7% vs. 48.3%) than those who received Clomid. Another important finding was that women who received Letrozole had live births of about 27.5% while women who received Clomid had live birth of about 19%. Letrazole was noted to be more efficient that Clomid for women with PCOS.

During this recent study, no significant differences in birth defects, pregnancy loss or twin pregnancies were noted between the groups that received Clomid or Letrazole. This recent study suggests that Letrozole is a safe and efficient medication that can be used as a first line treatment for women with PCOS who are trying to conceive.

Get In Touch

Rate, Review & Explore

Bloomingdale Office

471 W. Army Trail Rd
Ste 105
Bloomingdale, IL 60108

Open Today 8:00am - 4:00pm

Weekend by appointment

More Info Directions (630) 221-8131

Chicago Office

233 E Erie St
Ste 307
Chicago, IL 60611

Open Today 7:00am - 4:00pm

Weekend by appointment

More Info Directions (312) 664-0305

Elmhurst Office

1200 S York Rd
Ste 4260
Elmhurst, IL 60126

Closed Today

More Info Directions (630) 954-0048

Evanston Office

2500 Ridge Ave
Ste 308
Evanston, IL 60201

Open Today 8:00am - 4:00pm

Weekend by appointment

More Info Directions (847) 869-7777

Northbrook Office

1535 Lake Cook Rd
Ste 102
Northbrook, IL 60062

Open Today 8:00am - 4:00pm

Weekend by appointment

More Info Directions (224) 261-8710

Oak Brook Office

2425 W 22nd St
Ste 200
Oak Brook, IL 60523

Open Today 8:00am - 4:00pm

Weekend by appointment

More Info Directions (630) 954-0054

Oak Lawn Office

5851 W 95th St
Ste 117
Oak Lawn, IL 60453

Open Today 8:00am - 4:00pm

Weekend by appointment

More Info Directions (708) 741-7012