Treating the Problem Post-Implantation
After Implantation Chicago
Post-implantation pregnancy losses are manifest as early or late pregnancy losses after implantation. At our Chicago-area fertility centers, our experienced team works to determine the cause of post-implantation pregnancy loss and provide effective treatment for patients. Early pregnancy losses are losses of embryos during the first trimester of pregnancy and have been termed miscarriages. Although many advances in reproductive medicine have been made during the past 25 years, miscarriages remain the most common complication of pregnancy. While most miscarriages are sporadic and not repetitive, there is a subset of couples that suffer recurrent miscarriage. While the risk of miscarriage increases with maternal age, overall 15 percent of pregnancies miscarry. Approximately 13 percent of all recognized first pregnancies are lost. The risk of a second consecutive miscarriage is only slightly increased to 17 percent. However the risk of miscarriage after two consecutive pregnancy losses rises to 35 to 40 percent and continues to rise with each subsequent miscarriage. As many as 5 percent of all couples conceiving experience two consecutive miscarriages and 2 percent have three or more losses. Late pregnancy losses are losses of fetuses after the first trimester of pregnancy. Late pregnancy losses occur far less frequently than early pregnancy losses and comprise only 1 percent of pregnancies. Late pregnancy losses are usually associated with incompetent cervix, premature rupture of membranes, preterm labor, intrauterine growth retardation or placental abruption.
Causes of Recurrent Pregnancy Loss after Implantation
Historically, the cause of recurrent pregnancy loss after implantation was unknown in most couples. More recently, however, much progress has been made in understanding the mechanisms involved. Just as with pre-implantation and peri-implantation pregnancy loss, two major reasons for repeat post-implantation pregnancy loss exist. One is that there is something wrong with the pregnancy itself, such as a chromosomal abnormality that prohibits the pregnancy from implanting or growing properly. The other reason is a problem within in environment in which the pregnancy grows that does not allow an otherwise normal embryo to implant or grow properly. Problems within the uterine environment or lining of the uterus have been classified as anatomic, hormonal and immunologic.
Treatment of Recurrent Pregnancy Loss after Implantation
Effective treatment of recurrent pregnancy loss after implantation at the Chicago-area centers of Reproductive Medicine Institute depends on the cause of the pregnancy loss. If the cause of the pregnancy loss is a problem within the embryo itself, elimination of the problem involves treatments including donor egg, donor sperm or IVF with pre-implantation genetic diagnosis (PGD). If, however, the cause is related to activated immune cells and their cytokines, treatments include: Intravenous Immunoglobulin (IVIg), Intralipid, and Phosphodiesterase Inhibitors. If either acquired or inherited thrombophilia is causing clotting of the placental vessel and subsequent pregnancy loss, then heparin and aspirin is the treatment of choice. If the blood clotting is the result of an immune process, then steroids and/or IVIg can be used.
Learn More about Recurrent Pregnancy Loss after Implantation
If you are suffering recurrent pregnancy loss, especially after implantation, you should consult one of our Chicago-area centers. Reproductive Medicine Institute has helped many patients conceive even after recurrent pregnancy loss. Please contact us today to schedule a personal consultation with one of our fertility specialists.